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TL;DR: "The 'right' dose is the dose that is both maximally tolerated and achieves individualized patient’s goals for good sugar and weight control," Dr. Shenoy says.
Although many earlier drugs were stimulants such as amphetamines, in the early 2020s, GLP-1 receptor agonists became popular for weight loss. The medications liraglutide, [4] naltrexone/bupropion, [5] orlistat, [6] semaglutide, [7] and tirzepatide [8] are approved by the US Food and Drug Administration (FDA) for weight management in combination ...
In March 2023, a Novo Nordisk official said, based on a randomized, double-blind study (NCT03548935 [107]) funded by the company, that patients using semaglutide to lose weight regained two-thirds of their original weight loss one year (52 weeks) after discontinuing use of the drug. After two years (120 weeks), the patients retained roughly one ...
Model-Informed Precision Dosing (MIPD for short) is the use of pharmacometric models with computer software to optimize drug dosage for an individual patient. [1]Developed in the late 1960s under the impetus of clinical pharmacologists such as Lewis Sheiner and Roger Jelliffe, these approaches involve applying the equations and parameters describing a drug's pharmacokinetics and ...
Prescription drug doses are often based on body weight. [3] Drugs come with a recommended dose in milligrams or micrograms per kilogram of body weight, and that is used in conjunction with the patient's age and body weight to determine a safe dose. In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram ...
In the US, the drug label contains warnings for increased heart rate, suicidal behavior and ideation, glaucoma, mood and sleep disorders, creatinine elevation, and metabolic acidosis. Some of these warnings are based on historical observations in epilepsy patients taking topiramate.
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An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]