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Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, [1] [2] is a skin disease characterized by the sudden onset of fever, an elevated white blood cell count, and tender, red, well-demarcated papules and plaques that show dense infiltrates by neutrophil granulocytes on histologic examination.
Reactive neutrophilic dermatoses are a spectrum of conditions mediated by neutrophils, and typically associated with underlying diseases, such as inflammatory bowel disease and hematologic malignancy.
Sweet's syndrome-like dermatosis is a cutaneous condition associated with bowel disorders. [1] See also. Sweet's syndrome; List of cutaneous conditions; References
LPIN2, D18S60. Synonyms: Majeed syndrome. Complement component 2 deficiency: Possibly symptomatic of autoimmune diseases, but not a disease. Congenital heart block: May be related to autoimmune activity in the mother. Contact dermatitis: A hypersensitivity. Cushing's syndrome: No consistent evidence of association with autoimmunity.
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Autoinflammatory diseases (AIDs) are a group of rare disorders caused by dysfunction of the innate immune system.These responses are characterized by periodic or chronic systemic inflammation, usually without the involvement of adaptive immunity.
Additional causes include neutrophilic skin conditions such as pyoderma gangrenosum or Sweet's syndrome; vasculitic processes such as cryoglobulinemia; calciphylaxis (often seen in people with end-stage kidney disease but may also occur with medications such as warfarin); cancers such as squamous cell carcinoma (Marjolin's ulcer) or ...
Immune reconstitution syndrome commonly presents after microbiological control of infection (in cases of immune-suppressing pathogens such as HIV) but the syndrome may also present after organ transplant, in the post-partum state, with formerly neutropenic hosts or withdrawing anti-TNF therapy.