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The journal publishes mainly original research articles, and accepts papers covering all aspects of the interactions of chemicals with biological systems. John Jacob Abel founded ASPET in December 1908 when he invited 18 pharmacologists to his laboratory in order to organize a new society. [ 1 ]
The third mechanism involves two proteins, PtiA and PtiB, that target the LtrC, which is responsible for the production of virion and lysis proteins. This interference mechanism is modulated by a modulatory protein, PtiM, binds to one of the interference-mediating proteins, PtiA, and hence achieves the required level of interference. [176]
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. [2] A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor . [ 3 ]
Life Sciences is a weekly peer-reviewed scientific journal covering research on the molecular, cellular, and physiological mechanisms of pharmacotherapy. It was started in 1962 by Pergamon Press. According to the Journal Citation Reports, Life Sciences has a 2021 impact factor of 6.780. [1] The current Editor in Chief is Loren E. Wold. [2]
Population pharmacokinetics seeks to identify the measurable pathophysiologic factors and explain sources of variability that cause changes in the dose-concentration relationship and the extent of these changes so that, if such changes are associated with clinically relevant and significant shifts in exposures that impact the therapeutic index ...
The treatment focuses on the integration of split-off parts of self and object representations, and the consistent interpretation of these distorted perceptions is considered the mechanism of change. TFP has been validated as an efficacious treatment for BPD, [ 2 ] [ 3 ] but too few studies have been conducted to allow firm conclusions about ...
However, the modalities can be combined; antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy. Another form of targeted therapy involves the use of nanoengineered enzymes to bind to a tumor cell such that the body's natural cell degradation process can digest the cell, effectively eliminating it from the ...
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through splicing site binding on pre-mRNA ...