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  2. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Rivaroxaban binding to FXa is mediated through two hydrogen bonds to the amino acid Gly-219. These two hydrogen bonds serve an important role directing the drug into the S1 and S4 subsites of FXa. The first hydrogen bond is a strong interaction which comes from the carbonyl oxygen of the oxazolidinone core of rivaroxaban.

  3. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

  4. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

  5. Andexanet alfa - Wikipedia

    en.wikipedia.org/wiki/Andexanet_alfa

    Andexanet alfa, sold under the brand name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. [8] It has not been found to be useful for other factor Xa inhibitors. [9] It is given by injection into a vein. [9]

  6. Vitamin K antagonist - Wikipedia

    en.wikipedia.org/wiki/Vitamin_K_antagonist

    We undertook a post-hoc analysis of data from the ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation, n = 14,624) for stroke or non-CNS embolism within 30 days after temporary interruptions of 3 days or more, early permanent ...

  7. Cialis and Alcohol: Is it Safe?

    www.aol.com/lifestyle/cialis-alcohol-safe...

    How Cialis Works. Cialis is a prescription medication designed to treat ED. It’s approved for this use by the U.S. Food and Drug Administration (FDA). Tadalafil is the active ingredient in Cialis.

  8. Talk:Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Talk:Rivaroxaban

    The advantages of rivaroxaban vs. warfarin are others: no need of frequent INR measuring, simpler dosing scheme, much fewer interactions etc. However, the Systematic reviews section also sounds to me as if rivaroxaban had no advantages at all, which simply is not true.

  9. Alcohol is not good for us. 5 tips to stay safe(r) if you drink

    www.aol.com/drink-not-drink-5-tips-142139741.html

    That equals about 12 ounces of regular beer (at 5% alcohol; some light beers have less) or 5 ounces of wine (at 12% alcohol) or 1.5 ounces of distilled spirits (at 40% alcohol or 80 proof ...

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