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The plasma levels of the prodrug peak after about half an hour, and decline with a half-life of approximately 25 minutes, while the metabolite reaches peak blood concentrations about 1 to 2 hours after a dose of midodrine and has a half-life of about 3 to 4 hours. The absolute bioavailability of midodrine (measured as desglymidodrine) is 93%. [1]
"After-Birth Abortion: Why Should the Baby Live?" [1] is a controversial article published by Francesca Minerva and Alberto Giubilini. Available online from 2012 and published in the Journal of Medical Ethics in 2013, [ 2 ] it argues to call child euthanasia or infanticide "after-birth abortion" and highlights similarities between abortion and ...
Rectally administered misoprostol was reported in a variety of case reports and randomised controlled trials. [ 46 ] [ 47 ] However, it is inexpensive and thermostable (thus does not require refrigeration like oxytocin), making it a cost-effective and valuable drug to use in the developing world. [ 48 ]
Many oral forms of medications can be crushed and suspended in water to be given via a rectal catheter. The rectal route of administration is useful for patients with any digestive tract motility problem, such as dysphagia , ileus , or bowel obstruction , that would interfere with the progression of the medication through the tract.
Isabella of Hainault rests after having given birth to the future Louis VIII of France.. Postpartum confinement is a traditional practice following childbirth. [1] Those who follow these customs typically begin immediately after the birth, and the seclusion or special treatment lasts for a culturally variable length: typically for one month or 30 days, [2] 26 days, up to 40 days, two months ...
As the fetal hypothalamus matures, the activation of the hypothalamic–pituitary–adrenal (HPA) axis initiates labor through two hormonal mechanisms. The end pathway of both mechanisms lead to contractions in the myometrium, a mechanical cause of placental separation, which is due to the sheer force and contractile and involutive changes that occur within the uterus, distorting the placentome.
Six months after giving birth, one quarter of American women said they had lower sexual sensation, satisfaction, and ability to reach orgasm, and 22% said that sex was painful. More than 80% of British women experienced sexual problems three months after giving birth, and nearly two-thirds at six months, compared to pre-pregnancy levels of 38% ...
Pain management during childbirth is the partial treatment and a way of reducing any pain that a woman may experience during labor and delivery.The amount of pain a woman feels during labor depends partly on the size and position of her baby, the size of her pelvis, her emotions, the strength of the contractions, and her outlook. [1]
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