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Stereocilia (or stereovilli or villi) are non-motile apical cell modifications. They are distinct from cilia and microvilli , but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal cell membrane characteristics.
Resembling hair-like projections, the stereocilia are arranged in bundles of 30–300. [3] Within the bundles the stereocilia are often lined up in several rows of increasing height, similar to a staircase. At the core of these hair-like stereocilia are rigid cross-linked actin filaments, which can renew every
161497 140476 Ensembl ENSG00000242866 ENSMUSG00000033498 UniProt Q7RTU9 Q8VIM6 RefSeq (mRNA) NM_153700 NM_080459 RefSeq (protein) NP_714544 NP_536707 Location (UCSC) Chr 15: 43.6 – 43.62 Mb Chr 2: 121.19 – 121.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Stereocilin is a protein that in humans is encoded by the STRC gene. The STRC gene provides instructions for creating a ...
The hair cells have a hair bundle at the apical surface of the cell. The hair bundle consists of an array of actin-based stereocilia. Each stereocilium inserts as a rootlet into a dense filamentous actin mesh known as the cuticular plate. Disruption of these bundles results in hearing impairments and balance defects.
The macula of saccule lies in a nearly vertical position. It is a 2mm by 3mm patch of hair cells. Each hair cell of the macula contains 40 to 70 stereocilia and one true cilia, called a kinocilium. A gelatinous cover called the otolithic membrane envelops the tips of the stereocilia and kinocilium.
the cochlear duct or scala media (containing endolymph) a region of high potassium ion concentration that the stereocilia of the hair cells project into; The helicotrema, the location where the tympanic duct and the vestibular duct merge, at the apex of the cochlea; Reissner's membrane, which separates the vestibular duct from the cochlear duct
As a result, the cupula is deflected opposite the direction of head movement. As the endolymph pushes the cupula, the stereocilia is bent as well, stimulating the hair cells within the crista ampullaris. After a short time of continual rotation however, the endolymph's acceleration normalizes with the rate of rotation of the semicircular ducts.
The stereocilia are oriented by the striola, a curved ridge that runs through the middle of the macula; in the saccule they are oriented away from the striola [2] The tips of the stereocilia and kinocilium are embedded in a gelatinous otolithic membrane. This membrane is weighted with protein-calcium carbonate granules called otoliths, which ...