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The antiemetic action of metoclopramide is due to its antagonist activity at D 2 receptors in the chemoreceptor trigger zone in the central nervous system — this action prevents nausea and vomiting triggered by most stimuli. [35] At higher doses, 5-HT 3 antagonist activity may also contribute to the antiemetic effect. [36] [failed verification]
In the 1970s, John Fozard found that metoclopramide and cocaine were weak antagonists at the 5-HT 3 (5-HT-M) receptor. Fozard and Maurice Gittos later synthesized MDL 72222, the first potent and truly selective 5-HT 3 receptor antagonist. [35] [36] The antiemetic effects of metoclopramide were found to be partially because of its serotonin ...
The combination is used to treat the symptoms of migraine, both to relieve headache (the analgesic) and to treat associated nausea and vomiting (the antiemetic). In addition to its direct anti-emetic effect metoclopramide also stimulates gastric emptying ( prokinetic ), which is often delayed during migraine attacks, and accelerates the ...
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer. They may be used for severe cases of gastroenteritis, especially if the patient is dehydrated. [1] [2]
Domperidone is a peripherally selective dopamine D 2 receptor antagonist used as an antiemetic, gastroprokinetic agent and galactagogue. Bromopride binds enteric D 2 receptors [28] and also treats gastroparesis. [1] Metoclopramide also treats gastroparesis [1]
Other anti-dopaminergic drugs, like the antiemetic metoclopramide, can also result in extrapyramidal side effects. [6] Short and long-term use of antidepressants such as selective serotonin reuptake inhibitors (SSRI), serotonin-norepinephrine reuptake inhibitors (SNRI), and norepinephrine-dopamine reuptake inhibitors (NDRI) have also resulted ...
Metopimazine is an approved prescription drug in France under the brand name Vogalene® [8] that has been used for the treatment of nausea and vomiting. [9] Vogalene® is available under different forms, including 15 mg capsules, 7.5 mg orally disintegrating tablets, 5 mg suppository, 0.1% oral liquid, and a 10 mg/mL intravenous (IV) solution approved for the prevention of chemotherapy-induced ...
Trimethobenzamide (trade names Tebamide, Tigan) is an antiemetic used to prevent nausea and vomiting. ... Metoclopramide; References External links. Tebamide; Tigan ...
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