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Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
Green explains that the duration of a single session depends on the dose and can range from 45 minutes to 90 minutes, and the number of sessions recommended varies based on the goals of the treatment.
The recommended dosage of Spravato is 56 mg on day 1, 56 or 84 mg twice per week during weeks 1 to 4, 56 or 84 mg once per week during weeks 5 to 8, and 56 or 84 mg every 2 weeks or once weekly during week 9 and thereafter. [10] Dosing is individualized to the least frequent dosing necessary to maintain response or remission. [10]
Ketamine potentiates the sedative effects of propofol [85] and midazolam. [86] Naltrexone potentiates psychotomimetic effects of a low dose of ketamine, [87] while lamotrigine [38] and nimodipine [39] decrease them. Clonidine reduces the increase of salivation, heart rate, and blood pressure during ketamine anesthesia and decreases the ...
The researchers looked at data on 424 people with treatment-resistant depression who were treated between November 2017 and May 2021 at three ketamine infusion clinics in Virginia that specialize ...
Oral ketamine, supplied as a liquid which can be taken at home, can help maintain the benefit of infusions As with conventional antidepressants, regular treatment over several years is often ...
Five subjects dropped out of the ketamine study; of these, four were taking valproate and one was being treated with lithium. One patient showed signs of hypomania following ketamine administration and two experienced low mood. This study demonstrates a rapid-onset antidepressant effect of ketamine in a small group of patients with bipolar ...
MDMA-assisted psychotherapy is also currently in Phase 2 trials for eating disorders, [11] anxiety associated with life-threatening illness, [12] and social anxiety in autistic adults. [ 13 ] Psilocybin , a compound in psilocybin mushrooms that serves as a prodrug for psilocin , is currently being investigated in clinical trials of Hallucinogen ...