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A decongestant, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract.The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed effectiveness).
Phenylephrine, sold under the brand names Neosynephrine and Sudafed PE among others, is a medication used as a decongestant for uncomplicated nasal congestion in the form of a nasal spray or oral tablet, [5] to dilate the pupil, to increase blood pressure given intravenously in cases of low blood pressure, and to relieve hemorrhoids as a suppository.
[24] [2] [25] [1] As such, it is an indirectly acting sympathomimetic. [24] [2] [25] [1] Pseudoephedrine significantly crosses into the brain, but has some peripheral selectivity due to its hydrophilicity. [25] [26] Chemically, pseudoephedrine is a substituted amphetamine and is closely related to ephedrine, phenylpropanolamine, and amphetamine.
A Clarinase Repetab tablet contains 5 mg loratadine in the tablet coating and 120 mg pseudoephedrine sulfate equally distributed between the tablet coating and the barrier-coated core. The two active components in the coating are quickly liberated; release of pseudoephedrine in the core is delayed for several hours.
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Until 2006, NyQuil Cold/Flu Multisymptom Relief and NyQuil Sinus contained pseudoephedrine (30 mg/15 mL), a nasal decongestant that also formed the active ingredient in Sudafed. Following the passage of the Combat Methamphetamine Epidemic Act in 2006, in the United States all pseudoephedrine-containing medications must be kept behind a pharmacy ...
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Some brand names include: Benylin, Sudafed, Robitussin and Vicks among others. [35] Most contain a number of active ingredients. [4] The Thai company Hatakabb produces the Takabb Anti-Cough Pill, which is a Chinese herbal medication. [36] Sudafed is a brand manufactured by McNeil Laboratories.