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Thereafter, the otic cup closes off, creating the otic vesicle. Once formed, the otic vesicle will reside next to the neural tube medially, and on the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across ...
Around the 28th day, parts of the otic vesicle begin to form the vestibulocochlear nerve. [20] [22] These form bipolar neurons, which supply sensation to parts of the inner ear (namely the sensory parts of the semicircular canals, macular of the utricle and saccule, and organ of Corti). [20] Around the 33rd day, the vesicles begin to differentiate.
The cochlear duct develops from the ventral otic vesicle (otocyst). [3] It grows slightly flattened between the middle and outside of the body. [3] This development may be regulated by the genes EYA1, SIX1, GATA3, and TBX1. [3] The organ of Corti develops inside the cochlear duct. [4]
The otic vesicles then form ventral and dorsal components. The ventral component forms the saccule and the cochlear duct . In the sixth week of development the cochlear duct emerges and penetrates the surrounding mesenchyme , travelling in a spiral shape until it forms 2.5 turns by the end of the eighth week.
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The lateral semicircular canal (also known as horizontal or external semicircular canal) is the shortest of the three canals.Movement of fluid within its duct corresponds to rotation of the head around a vertical axis (i.e. the neck), or in other words, rotation in the transverse plane.
The eyes begin to develop as a pair of diverticula (pouches) from the lateral aspects of the forebrain.These diverticula make their appearance before the closure of the anterior end of the neural tube; [1] [2] after the closure of the tube around the 4th week of development, they are known as the optic vesicles.
These brain vesicles further divide into subregions. The prosencephalon gives rise to the telencephalon and diencephalon, and the rhombencephalon generates the metencephalon and myelencephalon. The hindbrain, which is the evolutionarily most ancient part of the chordate brain, also divides into different segments called rhombomeres.