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Bag and contents of a well-known early brand of synthetic cannabinoids named k2 spice that contains herbs covered with synthetic cannabinoids, now illegal throughout much of the world. Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants ...
When synthetic cannabinoids are used recreationally, they present significant health dangers to users. [100] In the period of 2012 through 2014, over 10,000 contacts to poison control centers in the United States were related to use of synthetic cannabinoids. [100] Medications containing natural or synthetic cannabinoids or cannabinoid analogs:
Hash oil or cannabis oil is an oleoresin obtained by the extraction of cannabis or hashish. [1] It is a cannabis concentrate containing many of its resins and terpenes – in particular, tetrahydrocannabinol (THC), cannabidiol (CBD), and other cannabinoids. Hash oil is usually consumed by smoking, vaporizing or eating. [2]
Synthetic cannabinoids are known under a variety of names including K2, Spice, Black Mamba, Bombay Blue, Genie, Zohai, [38] Banana Cream Nuke, Krypton, and Lava Red. [39] They are often called "synthetic marijuana," "herbal incense," or "herbal smoking blends" and often labeled "not for human consumption."
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
Cannabinoids and their K i values [a]; Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x): JWH-007 [5]: Naphthoylindole: 9.5 ± 4.5
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Efforts to isolate the active ingredients in cannabis were made in the 19th century. [87] Cannabidiol was studied in 1940 from Minnesota wild hemp [87] and Egyptian Cannabis indica resin. [88] [89] The chemical formula of CBD was proposed from a method for isolating it from wild hemp. [87] Its structure and stereochemistry were determined in ...