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  2. Polygene - Wikipedia

    en.wikipedia.org/wiki/Polygene

    Polygenic inheritance occurs when one characteristic is controlled by two or more genes. Often the genes are large in quantity but small in effect. [9] Examples of human polygenic inheritance are height, skin color, eye color and weight. Polygenes exist in other organisms, as well.

  3. Quantitative trait locus - Wikipedia

    en.wikipedia.org/wiki/Quantitative_trait_locus

    Polygenic inheritance can be explained as Mendelian inheritance at many loci, [9] resulting in a trait which is normally-distributed. If n is the number of involved loci, then the coefficients of the binomial expansion of ( a + b ) 2n will give the frequency of distribution of all n allele combinations .

  4. Genetic disorder - Wikipedia

    en.wikipedia.org/wiki/Genetic_disorder

    On a pedigree, polygenic diseases do tend to "run in families", but the inheritance does not fit simple patterns as with Mendelian diseases. This does not mean that the genes cannot eventually be located and studied. There is also a strong environmental component to many of them (e.g., blood pressure). Other such cases include: asthma

  5. Parkinson’s, ADHD tied to genes that affect brain volume

    www.aol.com/parkinson-adhd-tied-genes-affect...

    “One major limitation is the incomplete capture of genetic factors by polygenic scores. They might miss out on rare genetic variants or the interactions between different genes. These scores do ...

  6. Multifactorial disease - Wikipedia

    en.wikipedia.org/wiki/Multifactorial_disease

    In fact, the terms 'multifactorial' and 'polygenic' are used as synonyms and these terms are commonly used to describe the architecture of disease causing genetic component. [2] Multifactorial diseases are often found gathered in families yet, they do not show any distinct pattern of inheritance.

  7. Complex traits - Wikipedia

    en.wikipedia.org/wiki/Complex_traits

    When Mendel's work on inheritance was rediscovered in 1900, scientists debated whether Mendel's laws could account for the continuous variation observed for many traits. [citation needed] One group known as the biometricians argued that continuous traits such as height were largely heritable, but could not be explained by the inheritance of single Mendelian genetic factors.

  8. Non-Mendelian inheritance - Wikipedia

    en.wikipedia.org/wiki/Non-Mendelian_inheritance

    Polygenic means "many genes" are necessary for the organism to develop the trait. For example, at least three genes are involved in making the reddish-brown pigment in the eyes of fruit flies. Polygenic traits often show a wide range of phenotypes.

  9. Polygenic adaptation - Wikipedia

    en.wikipedia.org/wiki/Polygenic_adaptation

    At present the best-understood examples of polygenic adaptation are in humans, and particularly for height, a trait that can be interpreted using data from genome-wide association studies. In a 2012 paper, Joel Hirschhorn and colleagues showed that there was a consistent tendency for the "tall" alleles at genome-wide significant loci to be at ...