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  2. Structure and genome of HIV - Wikipedia

    en.wikipedia.org/wiki/Structure_and_genome_of_HIV

    The genome and proteins of HIV (human immunodeficiency virus) have been the subject of extensive research since the discovery of the virus in 1983. [1] [2] "In the search for the causative agent, it was initially believed that the virus was a form of the Human T-cell leukemia virus (HTLV), which was known at the time to affect the human immune system and cause certain leukemias.

  3. p24 capsid protein - Wikipedia

    en.wikipedia.org/wiki/P24_capsid_protein

    The HIV capsid consists of roughly 2000 copies of the p24 protein. The p24 structure is shown in two representations: cartoon (top) and isosurface (bottom) The p24 capsid protein is the most abundant HIV protein with each virus containing approximately 1,500 to 3,000 p24 molecules. [1]

  4. HIV - Wikipedia

    en.wikipedia.org/wiki/HIV

    Two types of HIV have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was initially discovered and termed both lymphadenopathy associated virus (LAV) and human T-lymphotropic virus 3 (HTLV-III). HIV-1 is more virulent and more infective than HIV-2, [20] and is the cause of the majority of HIV infections globally. The lower ...

  5. Envelope glycoprotein GP120 - Wikipedia

    en.wikipedia.org/wiki/Envelope_glycoprotein_GP120

    Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of HIV vaccine research. Efforts to develop HIV vaccines targeting gp120, however, have been hampered by the chemical and structural properties of gp120, which make it difficult for antibodies to bind to it. gp120 can also easily be shed from the surface of the virus and captured by T cells ...

  6. Gp41 - Wikipedia

    en.wikipedia.org/wiki/Gp41

    Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV). Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells.

  7. HIV/AIDS - Wikipedia

    en.wikipedia.org/wiki/HIV/AIDS

    Diagram of an HIV virion structure Scanning electron micrograph of HIV-1, colored green, budding from a cultured lymphocyte. HIV is the cause of the spectrum of disease known as HIV/AIDS. HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells.

  8. Group-specific antigen - Wikipedia

    en.wikipedia.org/wiki/Group-specific_antigen

    HIV MA also makes contacts with the HIV trans-membrane glycoprotein gp41 in the assembled virus and, indeed, may have a critical role in recruiting Env glycoproteins to viral budding sites. [citation needed] Once Gag is translated on ribosomes, Gag polyproteins are myristoylated at their N-terminal glycine residues by N-myristoyltransferase 1 ...

  9. Integrase - Wikipedia

    en.wikipedia.org/wiki/Integrase

    Structural depiction of the HIV catalytic core domain based on the works of Feng, L. and Kvaratskhelia, M. from the protein database. HIV integrase is a 32kDa viral protein consisting of three domains- N-terminus, catalytic core domain, and C-terminus, which each have distinct properties and functions contributing to the efficacy of HIV ...

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