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Benzathine benzylpenicillin, also known as benzathine penicillin G (BPG), is an antibiotic medication useful for the treatment of a number of bacterial infections. [3] Specifically it is used to treat strep throat, diphtheria, syphilis, and yaws. [3] [5] It is also used to prevent rheumatic fever. [5] It is given by injection into a muscle.
Specific indications for procaine penicillin include: [6] Syphilis. In the United States, Bicillin C-R (an injectable suspension which 1.2 million units of benzathine penicillin and 1.2 million units of procaine penicillin per 4 ml) is not recommended for treating syphilis, since it contains only half the recommended dose of benzathine penicillin.
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
Benzathine is a diamine used as a component in some medications including benzathine phenoxymethylpenicillin and benzathine benzylpenicillin. It stabilizes penicillins and increases the half-life . [ 1 ]
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
Therefore, 2 million units (2 megaunits) of penicillin G is 1.2 g. [22] One unit of penicillin V potassium is defined as 0.625 micrograms. Therefore 400,000 units of penicillin V is 250 mg. [23] The use of units to prescribe penicillin is a historical accident and is largely obsolete outside of the US.
Benzylpenicillin, also known as penicillin G (PenG [4]) or BENPEN, [5] is an antibiotic used to treat a number of bacterial infections. [6] This includes pneumonia , strep throat , syphilis , necrotizing enterocolitis , diphtheria , gas gangrene , leptospirosis , cellulitis , and tetanus . [ 6 ]
The simplest β-lactam possible is 2-azetidinone. β-lactams are significant structural units of medicines as manifested in many β-lactam antibiotics. [2] Up to 1970, most β-lactam research was concerned with the penicillin and cephalosporin groups, but since then, a wide variety of structures have been described. [3] [4]
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