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Streptomyces griseus is a species of bacteria in the genus Streptomyces commonly found in soil. A few strains have been also reported from deep-sea sediments. It is a Gram-positive bacterium with high GC content .
Streptomyces is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. [3] Over 700 species of Streptomyces bacteria have been described. [ 4 ] [ 5 ] [ 6 ] As with the other Actinomycetota, streptomycetes are gram-positive , and have very large genomes with high GC content .
Actinomycetota, especially Streptomyces spp., are recognized as the producers of many bioactive metabolites that are useful to humans in medicine, such as antibacterials, [18] antifungals, [19] antivirals, antithrombotics, immunomodifiers, antitumor drugs, and enzyme inhibitors; and in agriculture, including insecticides, herbicides, fungicides ...
Streptomyces griseofuscus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Japan. [ 1 ] [ 2 ] Streptomyces griseofuscus produces azinomycin A , azinomycin B , bundlin A , bundlin B , moldicidin A , physostigmine , fungichromin and pentamycin .
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Cycloheximide is a naturally occurring fungicide produced by the bacterium Streptomyces griseus.Cycloheximide exerts its effects by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome), thus blocking eukaryotic translational elongation.
As human and bacteria both have ribosomes, streptomycin has significant side effects in humans. At low concentrations, however, streptomycin inhibits only bacterial growth. [18] Streptomycin is an antibiotic that inhibits both Gram-positive and Gram-negative bacteria, [19] and is therefore a useful broad-spectrum antibiotic.
Streptomyces isolates have yielded the majority of human, animal, and agricultural antibiotics, as well as a number of fundamental chemotherapy medicines. Streptomyces is the largest antibiotic -producing genus of Actinomycetota , producing chemotherapy, antibacterial, antifungal , antiparasitic drugs, and immunosuppressants . [ 1 ]