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Factor V Leiden is an autosomal dominant genetic condition that exhibits incomplete penetrance, i.e. not every person who has the mutation develops the disease. The condition results in a factor V variant that cannot be as easily degraded by activated protein C. The gene that codes the protein is referred to as F5.
286.3 Congenital deficiency of other clotting factors. Factor XIII deficiency; 286.4 Von Willebrand's disease; 286.5 Hemorrhagic disorder due to intrinsic anticoagulants; 286.6 Defibrination syndrome; 286.7 Acquired coagulation factor deficiency; 286.9 Coagulation defects, other; 287 Purpura and other hemorrhagic conditions. 287.0 Allergic ...
Methylenetetrahydrofolate reductase deficiency is the most common genetic cause of elevated serum levels of homocysteine (hyperhomocysteinemia). It is caused by genetic defects in MTHFR, which is an important enzyme in the methyl cycle. [1] Common variants of MTHFR deficiency are asymptomatic and have only minor effects on disease risk. [2]
APC resistance is the inability of protein C to cleave Factor Va and/or Factor VIIIa, which allows for longer duration of thrombin generation and may lead to a hypercoagulable state. This may be hereditary or acquired. [4] The best known and most common hereditary form is Factor V Leiden, which is responsible for more than 95% of cases. [5]
The type of haemophilia known as parahaemophilia is a mild and rare form and is due to a deficiency in factor V. This type can be inherited or acquired. [10] A non-genetic form of haemophilia is caused by autoantibodies against factor VIII and so is known as acquired haemophilia A. [15]
Hypoprothrombinemia can be the result of a genetic defect, may be acquired as the result of another disease process, or may be an adverse effect of medication.For example, 5-10% of patients with systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant ...
“Pregnant women and women trying to conceive should be taking prenatal vitamins. The most important reason is the folate supplementation,” says s Shanna Levine, M.D. , primary care physician ...
One factor is an adverse reaction to the hormonal changes of pregnancy, in particular, elevated levels of beta human chorionic gonadotropin (β-hCG). [ 27 ] [ 28 ] This theory would also explain why hyperemesis gravidarum is most frequently encountered in the first trimester (often around 8–12 weeks of gestation), as β-hCG levels are highest ...