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CCR2 surface expression on blood monocytes changes in a time-of-day–dependent manner (being higher at the beginning of the active phase) and affects monocytes recruitment in tissues including the heart. As a consequence when an acute ischemic event happens during the active phase, monocytes are more susceptible to invade the heart. [10]
CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times.
1235 12458 Ensembl ENSG00000112486 ENSMUSG00000040899 UniProt P51684 O54689 RefSeq (mRNA) NM_031409 NM_004367 NM_001394582 NM_001190333 NM_001190334 NM_001190335 NM_001190336 NM_001190337 NM_001190338 NM_009835 RefSeq (protein) NP_004358 NP_113597 NP_001177262 NP_001177263 NP_001177264 NP_001177265 NP_001177266 NP_001177267 NP_033965 Location (UCSC) Chr 6: 167.11 – 167.14 Mb Chr 17: 8.45 ...
The expression of CCL2 in neurons is mainly found in the cerebral cortex, globus pallidus, hippocampus, paraventricular and supraoptic hypothalamic nuclei, lateral hypothalamus, substantia nigra, facial nuclei, motor and spinal trigeminal nuclei, gigantocellular reticular nucleus and in Purkinje cells in the cerebellum.
54199 Ensembl ENSG00000121797 ENSMUSG00000043953 UniProt O00421 O35457 RefSeq (mRNA) NM_001130910 NM_003965 NM_017466 NM_001302376 NM_001302377 RefSeq (protein) NP_001124382 NP_003956 NP_001289305 NP_001289306 NP_059494 Location (UCSC) Chr 3: 46.41 – 46.41 Mb Chr 9: 110.88 – 110.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse C-C chemokine receptor-like 2 is a protein that in ...
CCL7 is a multipotent chemokine involved in anti-bacterial, anti-viral and anti-fungal immune responses. For example, CCL7-mediated stimulation of CCR2 chemokine receptors on monocytes is participating in the elimination of Listeria monocytogenes infections by the recruitment of monocytes and TNF/iNOS-producing dendritic cells (TipDCs). [20]
CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span the cell membrane seven times.
Other studies highlight the role of CXCR5 in T cells, as they are unable to access B cell follicles without CXCR5 expression. [ 9 ] [ 10 ] This is a key step in the production of high affinity antibodies as B cells and T cells need to interact in order to activate the Ig class switch.
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