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Dibenzodioxin is the carbon skeleton of the poisonous polychlorinated dibenzodioxins (PCDDs), often called dioxins. The most harmful PCDD is 2,3,7,8-tetrachlorodibenzodioxin (TCDD). Dioxins and dioxin-like compounds is a category of pollutants that includes PCDDs and other compounds that have similar structure, toxicity, and persistence.
Rifampicin is the INN and BAN, while rifampin is the USAN. Rifampicin may be abbreviated R, RMP, RA, RF, or RIF (US). [citation needed] Rifampicin is also known as rifaldazine, [63] [64] rofact, and rifampin in the United States, also as rifamycin SV. [65]
Polychlorinated dibenzodioxins (PCDDs), or simply dioxins, are a group of long-lived polyhalogenated organic compounds that are primarily anthropogenic, and contribute toxic, persistent organic pollution in the environment.
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Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
1,2-Dioxin or 1,4-Dioxin, two unsaturated heterocyclic 6-membered rings in which two carbon atoms have been replaced by oxygen atoms, which gives the molecular formula C 4 H 4 O 2; Dibenzo-1,4-dioxin, also known as dibenzodioxin or dibenzo-p-dioxin (molecular formula C 12 H 8 O 2), in which two benzene rings are connected through two oxygen atoms.
In non-resistant TB, rifampin binds the beta subunit of RNA polymerase and disrupts transcription elongation. Mutation in the rpoB gene changes the sequence of amino acids and eventual conformation, or arrangement, of the beta subunit. In this case, rifampin can no longer bind or prevent transcription, and the bacterium is resistant. [19] [20]
C 12 H 6 Cl 2 O: 2,7-dichlorodibenzofuran 74992-98-6 DOZUTNBCPVUMPY-UHFFFAOYSA-N PCDF-28 C 12 H 6 Cl 2 O: 2,8-dichlorodibenzofuran 5409-83-6 IVVRJIDVYSPKFZ-UHFFFAOYSA-N PCDF-34 C 12 H 6 Cl 2 O: 3,4-dichlorodibenzofuran 94570-83-9 HYQGGNWDPQZLGX-UHFFFAOYSA-N PCDF-36 C 12 H 6 Cl 2 O: 3,6-dichlorodibenzofuran 74918-40-4 DMOBGFAKTSXOHG-UHFFFAOYSA-N ...