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Members of the Argonaute (Ago) protein family are central to RISC function. Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the single stranded 3' end of the mature miRNA and a PIWI domain that structurally resembles ribonuclease-H and functions to interact with the 5 ...
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Function Distribution Ref. Small nuclear RNA: snRNA: Splicing and other functions: Eukaryotes and archaea [3] Small nucleolar RNA: snoRNA: Nucleotide modification of RNAs: Eukaryotes and archaea [4] SmY RNA: SmY: mRNA trans-splicing: Nematodes [5] Small Cajal body-specific RNA: scaRNA: Type of snoRNA; Nucleotide modification of RNAs: Guide RNA ...
It is concluded that the miRNA has an important function in the central pacemaker of the Drosophila circadian rhythm clock. To be more precise Bantam miRNA has an important relation with the clock component clk, thus making it an important factor of study regarding its role in Drosophila behavior.
An miRNA that remains constant in its expression through these stages is proposed to have a role in regulating general aspects of cell physiology. [8] Thus it was becoming evident in 2003 shortly after its discovery, that the mir-92 miRNA and associated family members are providing functional roles to the cell cycle and to cell signalling, and ...
n/a Ensembl ENSG00000207703 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 15: 88.61 – 88.61 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 7-2 is a non-protein-coding gene product that in humans is encoded by the MIR7-2 gene. Function microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional ...
A miRNA can be derived from each arm of the pre-miRNA hairpin. Historically, the least common of these two miRNA products was denoted by the addition of * to the miRNA name, however the modern convention is to denote mature miRNA products as 5p or 3p. [11] Both mir-10 and mir-10* have been detected in Drosophila.
Cupid is a method for simultaneous prediction of miRNA-target interactions and their mediated competing endogenous RNA (ceRNA) interactions. It is an integrative approach significantly improves on miRNA-target prediction accuracy as assessed by both mRNA and protein level measurements in breast cancer cell lines.