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Glioblastoma, previously known as glioblastoma multiforme (GBM), is the most aggressive and most common type of cancer that originates in the brain, and has a very poor prognosis for survival. [ 6 ] [ 7 ] [ 8 ] Initial signs and symptoms of glioblastoma are nonspecific. [ 1 ]
The best-known risk factor is exposure to ionizing radiation, and CT scan radiation is an important cause. [10] [11] The dose-response for the relationship between low-dose ionising radiation and glioma risk is a risk increase of 55% per 100 milligray of radiation. [10]
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor, accounting for about 15% of all primary malignant brain tumors. GBM invades normal brain tissue, so although it usually ...
Ionizing radiation to the head as part of treatment for other cancers is also a risk factor for developing brain cancer. [ 24 ] Mutations and deletions of tumor suppressor genes , such as P53 , are thought to be the cause of some forms of brain tumor. [ 28 ]
For example, bevacizumab is a targeted therapy drug used against various cancers, including glioblastoma, that blocks the blood supply to and therefore the proliferation of cancerous tumors. [ citation needed ] Checkpoint inhibitors , which prevent the tumor from blocking the action of tumor-killing cells of the immune system. are also being ...
Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain cells, as opposed to the neural brain cells. Gliosarcoma is a malignant cancer, and is defined as a glioblastoma consisting of gliomatous and sarcomatous components. [3]
The giant-cell glioblastoma is a histological variant of glioblastoma, presenting a prevalence of bizarre, multinucleated (more than 20 nuclei) giant (up to 400 μm diameter) cells. It occasionally shows an abundant stromal reticulin network and presents a high frequency of TP53 gene mutations .
Goldman Sachs hosted a meeting with Pfizer Inc’s (NYSE:PFE) newly appointed Chief Scientific Officer Chris Boshoff (effective January 1, 2025). The analyst maintains the Buy rating with a price ...
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