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Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
Nasal obstruction characterized by insufficient airflow through the nose can be a subjective sensation or the result of objective pathology. [10] It is difficult to quantify by subjective complaints or clinical examinations alone, hence both clinicians and researchers depend both on concurrent subjective assessment and on objective measurement of the nasal airway.
A combination of topical and systematic antibiotics taken prophylactically can prevent infection and improve adults' overall mortality in the ICU for adult patients receiving mechanical ventilation for at least 48 hours, and topical antibiotic prophylaxis probably reduces respiratory infections but not mortality. [24]
An acute exacerbation of COPD is associated with increased frequency and severity of coughing. [5] It is often accompanied by worsened chest congestion and discomfort. Shortness of breath and wheezing are present in many cases. [5] Exacerbations may be accompanied by increased amount of cough and sputum productions, and a change in appearance ...
Asthma being a reversible obstruction of airways is often considered separately, but many COPD patients also have some degree of reversibility in their airways. [ 7 ] In COPD, there is an increase in airway resistance , shown by a decrease in the forced expiratory volume in 1 second (FEV1) measured by spirometry .
The most prominent symptoms of nasal polyps is blockage of the nasal passage. [7] People with nasal polyps due to aspirin intolerance often have a disease known as aspirin-exacerbated respiratory disease, which consists of asthma and chronic nasal polyps along with a hypersensitivity reaction to aspirin. [5]
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