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About one in three people diagnosed with lung cancer have symptoms caused by metastases in sites other than the lungs. [7] Lung cancer can metastasize anywhere in the body, with different symptoms depending on the location. Brain metastases can cause headache, nausea, vomiting, seizures, and neurological deficits.
A brain metastasis is a cancer that has metastasized (spread) to the brain from another location in the body and is therefore considered a secondary brain tumor. [ 1 ] [ 2 ] The metastasis typically shares a cancer cell type with the original site of the cancer. [ 3 ]
Secondary, or metastatic, brain tumors are about four times as common as primary brain tumors, [2] [10] with about half of metastases coming from lung cancer. [2] Primary brain tumors occur in around 250,000 people a year globally, and make up less than 2% of cancers. [3]
Small-cell lung carcinoma (SCLC) has long been divided into two clinicopathological stages, termed limited stage (LS) and extensive stage (ES). [8] The stage is generally determined by the presence or absence of metastases, whether or not the tumor appears limited to the thorax, and whether or not the entire tumor burden within the chest can feasibly be encompassed within a single radiotherapy ...
Symptomatic features of paraneoplastic syndrome cultivate in four ways: endocrine, neurological, mucocutaneous, and hematological.The most common presentation is a fever (release of endogenous pyrogens often related to lymphokines or tissue pyrogens), but the overall picture will often include several clinical cases observed which may specifically simulate more common benign conditions.
Metastasis occurrence indicates stage 4 cancer progression and carries a poor prognosis. [7] Cancer usually causes numerous and varying symptoms at this stage depending on the underlying cancer and metastasis location. [7] Importantly for diagnosis, a symptomatic primary lesion is localised through either surgery or radiation. [7]
Most patients with limited-stage small cell lung cancer will receive a CT scan of the chest and abdomen to search for abnormality within the lungs and lymph nodes, as well as abnormal areas in more distal organs such as adrenal glands and liver that might arise from the metastasis of lung cancer. [15]
The included cancer types are the ones causing most death as per data from the US in 2008. [1] Lung cancer, mainly to adrenal glands, brain, and bone [2] Breast cancer, mainly to bone, liver, lung and brain. [3] Colon cancer, mainly to liver. [4] Pancreatic cancer, mainly to liver and lungs. [5] Melanoma, mainly to brain [6]