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Gottesman and Shields published Schizophrenia and Genetics to document their twin-study research at the Maudsley Hospital in London, the work that in part earned them the Hofheimer Prize for Research, [25] the highest award for psychiatric research from the American Psychiatric Association. [26]
James Shields (21 November 1918 – 20 June 1978) was a Scottish psychiatric geneticist and twin researcher. [1] In the 1960s, he worked with Irving Gottesman on a twin study of schizophrenia at the Medical Research Council Psychiatric Genetics Unit at Maudsley Hospital in London, England.
McGuffin and colleagues re-examined the classic Maudsley schizophrenia study of Gottesman and Shields at a time when there widespread questioning of a genetic component for schizophrenia on the basis that studies until then had used descriptive clinical diagnoses rather than modern operational criteria.
1994, Schizophrenia and Manic-Depressive Disorder: The Biological Roots of Mental Illness as Revealed by a Landmark Study of Identical Twins (senior author), with Irving I. Gottesman, Edward H. Taylor, Ann E. Bowler, Perseus Books Group; 1996, Out of the Shadows: Confronting America's Mental Illness Crisis, John Wiley & Sons, Inc., ISBN 0-471 ...
Irving I. Gottesman (1930–2016), US behavioral geneticist, used twin studies to analyze schizophrenia; Carol W. Greider (born 1961), US molecular biologist, Lasker Award and Nobel Prize for telomeres and telomerase; Jack Greenblatt (20-21st centuries), Molecular geneticist at the University of Toronto
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The power of twin designs arises from the fact that twins may be either identical (monozygotic (MZ), i.e. developing from a single fertilized egg and therefore sharing all of their polymorphic alleles) or fraternal (dizygotic (DZ), i.e. developing from two fertilized eggs and therefore sharing on average 50% of their alleles, the same level of genetic similarity found in non-twin siblings).
Exactly 10 years ago today, I published a commentary defending the decision to publish the contents of the Sony hack in Variety, the publication where I then served as co-editor-in-chief. Listen ...