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Triple-negative is sometimes used as a surrogate term for basal-like. [2] Triple-negative breast cancer comprises 15–20% of all breast cancer cases [3] and affects more young women or women with a mutation in the BRCA1 gene than other breast cancers. [4] Triple-negative breast cancers comprise a very heterogeneous group of cancers.
In women with metastatic breast cancer who do not have triple negative disease, there is little or no survival benefit and excess toxicity from platinum-based regimens. [23] However, in women with metastatic triple negative breast cancer, there may be a moderate survival benefit from platinum-based regimens. [23]
Triple negative breast cancer, in particular, has a worse prognosis and can be difficult to treat. There are few targeted therapies like there are for estrogen positive breast cancers, she says.
This is an accepted version of this page This is the latest accepted revision, reviewed on 2 January 2025. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Surgical Oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on ...
Triple-negative breast cancer acts aggressively, grows quickly, spreads further and is more likely to return, the American Cancer Society says. It often occurs in women younger than 40, Black ...
In the other 20-30%, the breast cancer will return as Stage 4, also known as metastatic, when the cancer has spread to other parts of the body beyond the lymph nodes near the breast. Metastatic ...
Conversely, triple negative cancer (i.e. no positive receptors), lacking targeted treatments, now has a comparatively poor prognosis. [42] [43] Androgen receptor is expressed in 80-90% of ER+ breast cancers and 40% of "triple negative" breast cancers. Activation of androgen receptors appears to suppress breast cancer growth in ER+ cancer while ...
April Donaldson, a 44-year-old metastatic cancer survivor, was introduced to Tomlin-Harris at an event after she was diagnosed with triple-negative breast cancer in 2020. After hearing another ...