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The T4 virus initiates an Escherichia coli infection by binding OmpC porin proteins and lipopolysaccharide (LPS) on the surface of E. coli cells with its long tail fibers (LTF). [16] [17] A recognition signal is sent through the LTFs to the baseplate. This unravels the short tail fibers (STF) that bind irreversibly to the E. coli cell surface.
The virus attaches to the host cell using its terminal fibers, and uses viral exolysin to degrade the cell wall enough to eject the viral DNA into the host cytoplasm via contraction of its tail sheath. DNA-templated transcription is the method of transcription. The virus exits the host cell by lysis, and holin/endolysin/spanin proteins. Once ...
Enterobacteria phage T6 is a bacteriophage strain that infects Escherichia coli bacteria. It was one bacteriophage that was used as a model system in the 1950s in exploring the methods viruses replicate, along with the other T-even bacteriophages (which build up virus species Escherichia virus T4, a member of genus T4virus according to ICTV nomenclature): [1] Enterobacteria phage T2 ...
Escherichia (/ ˌ ɛ ʃ ə ˈ r ɪ k i ə / ESH-ə-RIK-ee-ə) is a genus of Gram-negative, non-spore-forming, facultatively anaerobic, rod-shaped bacteria from the family Enterobacteriaceae. [3] In those species which are inhabitants of the gastrointestinal tracts of warm-blooded animals, Escherichia species provide a portion of the microbially ...
[1] [2] Due to the risks following caesarean section, it is recommended that all women receive a preventive dose of antibiotics such as ampicillin around the time of surgery. [1] Treatment of established infections is with antibiotics, with most people improving in two to three days. [1]
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The virus's virion have icosahedral (T=9) [1] heads ~70 nm and short tails (10 nm), and contain short fibers originating from the junction between the head and tail. All the phages of this genus are strictly virulent and contain a linear dsDNA genome (with terminal repeats) in the range of 70-75kb.
Viral replication is cytoplasmic. The virus attaches to the host cell adhesion receptors using its tail fibers, and ejects the viral DNA into the host periplasm via short tail system. Class I genes are transcribed by the host cell's RNA polymerase before the viral genome completely exits the capsid.