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Diagnosis relies on a combination of brain monitoring (electroencephalography)(EEG) and observing clinical signs or symptoms of a seizure. [4] EEG may be continuous or intermittent, and it may also be combined with video recording of the infant to correlate any seizure movements with EEG recordings. [4]
The epileptic seizure in the vast majority of pediatric epilepsy patients is ephemeral, and symptoms typically subside on their own after the seizure comes to an end, but some children experience what is known as a “seizure cluster," in which the first seizure is followed by a second episode approximately six hours later.
The key to diagnosis is a family history of similar events and a normal neurological exam. Seizures occur between a few days to a few weeks of life and resolve by 5 months of age (range 5 days to 2 years). An EEG taken between seizures is typically normal. [1] [3] Diagnostic testing is similar to that of self-limited neonatal seizures.
BFNS often presents in the first week of life with brief but frequent episodes of tonic-clonic seizures, outside of which a child is completely asymptomatic. [2] [3] [4] During the tonic phase of these seizures, infants may stop breathing and consequently appear blue due to lack of oxygen. Accompanying this is focal or generalized muscle ...
Benign familial infantile epilepsy (BFIE) is an epilepsy syndrome. [1] Affected children, who have no other health or developmental problems, develop seizures during infancy. These seizures have focal origin within the brain but may then spread to become generalised seizures. The seizures may occur several times a day, often grouped in clusters ...
Benign infantile epilepsy (BIE), also known as benign infantile seizures (BIS), is an epilepsy syndrome of which several forms have been described. The International League Against Epilepsy (ILAE) classify two main forms of the syndrome (familial and nonfamilial) [ 1 ] though several other forms have been described in the academic literature.
Malignant migrating partial seizures of infancy (MMPSI) is a rare epileptic syndrome that onsets before 6 months of age, commonly in the first few weeks of life. [3] Once seizures start, the site of seizure activity repeatedly migrates from one area of the brain to another, with few periods of remission in between.
Ohtahara syndrome (OS), also known as Early Infantile Developmental & Epileptic Encephalopathy (EIDEE) [2] is a progressive epileptic encephalopathy.The syndrome is outwardly characterized by tonic spasms and partial seizures within the first few months of life, [3] and receives its more elaborate name from the pattern of burst activity on an electroencephalogram (EEG).
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