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Sp100 nuclear antigen is an interferon stimulated antigen found in the cell nuclei of many human and higher animal cells. Autoantibodies directed against Sp100 are often found in patients with primary biliary cirrhosis. [1] Histologically Sp100 'dots' regions of the cell nucleus. Viral infection and mitogens affect the expression of the Sp100 ...
Anti-sp100 antibodies are found in association with primary biliary cirrhosis. [1] The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis . 20-30% of patients with primary biliary cirrhosis have sp100 Abs.
Anti-sp100 antibodies are found in approximately 20–30% of primary biliary cirrhosis (PBC). They are found in few individuals without PBC, and therefore are a very specific marker of the disease. The sp100 antigen is found within nuclear bodies; large protein complexes in the nucleus that may have a role in cell growth and differentiation. [47]
That nuclear bodies co-isolated with the nuclear matrix, and were linked to the fibrogranular nuclear matrix component by projections from the surface of the nuclear bodies. [11] The primary components of the nuclear dots are the proteins sp100 nuclear antigen, LYSP100(a homolog of sp100), [ 12 ] ISG20 , [ 13 ] PML antigen , NDP55 and 53kDa ...
Sp100 nuclear antigen: Anti-glycoprotein-210 antibodies [7] nucleoporin 210kDa: Anti-transglutaminase antibodies: Anti-tTG: celiac disease: Anti-eTG: dermatitis herpetiformis: Anti-ganglioside antibodies: ganglioside GQ1B: Miller Fisher syndrome: ganglioside GD3: acute motor axonal neuropathy (AMAN) ganglioside GM1: multifocal motor neuropathy ...
ENA (extractable nuclear antigen) panel tests, test for autoantibodies to proteins in the cell nucleus. The term "extractable" is derived from the ability to remove the autoantibodies from the nuclei with saline and common proteins. The method of identifying these specimens is why they are also referred to as antibodies to saline-extracted ...
Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate. Anti-SSA autoantibodies (anti–Sjögren's-syndrome-related antigen A autoantibodies, also called anti-Ro, or similar names including anti-SSA/Ro, anti-Ro/SSA, anti–SS-A/Ro, and anti-Ro/SS-A) are a type of anti-nuclear autoantibodies that are associated with ...
Types of monoclonal antibodies with other structures than naturally occurring antibodies. The abbreviations in the column Type are as follows: mab: whole monoclonal antibody; Fab: fragment, antigen-binding (one arm) F(ab') 2: fragment, antigen-binding, including hinge region (both arms) Fab': fragment, antigen-binding, including hinge region ...