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Sp100 nuclear antigen is an interferon stimulated antigen found in the cell nuclei of many human and higher animal cells. Autoantibodies directed against Sp100 are often found in patients with primary biliary cirrhosis. [1] Histologically Sp100 'dots' regions of the cell nucleus. Viral infection and mitogens affect the expression of the Sp100 ...
Anti-sp100 antibodies are found in association with primary biliary cirrhosis. [1] The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis . 20-30% of patients with primary biliary cirrhosis have sp100 Abs.
The primary components of the nuclear dots are the proteins sp100 nuclear antigen, LYSP100(a homolog of sp100), [12] ISG20, [13] PML antigen, NDP55 and 53kDa protein associated with the nuclear matrix. [14] Other proteins, such as PIC1/SUMO-1, which are associated with nuclear pore complex also associate with nuclear dots. [15]
SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene. [4] [5] [6] The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein ...
This protein domain has a conserved region of around 80 residues.Mutations in this region lead to various human diseases, particularly in these proteins: Sp100 (Speckled protein 100 kDa), NUDR (Nuclear DEAF-1 related), GMEB (Glucocorticoid Modulatory Element Binding) proteins and AIRE-1 (Autoimmune regulator 1) proteins.
6667 20683 Ensembl ENSG00000185591 ENSMUSG00000001280 UniProt P08047 O89090 RefSeq (mRNA) NM_001251825 NM_003109 NM_138473 NM_013672 RefSeq (protein) NP_001238754 NP_003100 NP_612482 NP_038700 Location (UCSC) Chr 12: 53.38 – 53.42 Mb Chr 15: 102.31 – 102.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor Sp1, also known as specificity protein 1* is a protein ...
Anti Scl-70 antibodies (also called anti-topoisomerase I after the type I topoisomerase target [1]) is a type of antinuclear autoantibody seen mainly in diffuse systemic scleroderma, but is also seen the more limited form of systemic scleroderma called CREST syndrome. [2]
19069 Ensembl ENSG00000108559 ENSMUSG00000040667 UniProt Q99567 Q8CEC0 RefSeq (mRNA) NM_002532 NM_001320653 NM_001083331 NM_001276406 NM_172394 RefSeq (protein) NP_001307582 NP_002523 NP_001076800 NP_001263335 NP_765982 Location (UCSC) Chr 17: 5.36 – 5.42 Mb Chr 11: 70.83 – 70.86 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nucleoporin 88 (Nup88) is a protein that in humans is ...
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related to: sp100 gene