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Members of the Argonaute (Ago) protein family are central to RISC function. Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the single stranded 3' end of the mature miRNA and a PIWI domain that structurally resembles ribonuclease-H and functions to interact with the 5 ...
The current evidence points toward P-bodies as being scaffolding centers of miRNA function, especially due to the evidence that a knock down of GW182 disrupts P-body formation. However, there remain many unanswered questions about P-bodies and their relationship to miRNA activity.
This image is an illustration of the Anti-miRNA bound to miRNA through hybridization. This is one of the couple ways in which AMOs can interact with miRNA in the body. By the hybridization of the miRNA sequence, the function of the miRNA sequence is neutralized by preventing its selective binding to the target genetic information.
A single miRNA can reduce the expression levels of hundreds of genes. The mechanism by which mature miRNA molecules act is through partial complementarity to one or more messenger RNA (mRNA) molecules, generally in 3' UTRs. The main function of miRNAs is to down-regulate gene expression.
While miR-125a acts as an oncogenic miRNA in non-blood cancers, its oncogenic functions have been described in cervical cancer, colorectal cancer, nasopharyngeal carcinoma and esophageal carcinomas. [5] On the other hand, high expression of miR-125b was shown to decrease cell proliferation and induces apoptosis.
MiRNA-210 inhibits the effects of Ptp1b protein, which suppresses its pro-apoptotic functions. [3] Therefore, suppression of these two particular genes may contribute to the improvement of cardiac tissue and function by up-regulating angiogenesis and inhibiting apoptosis of cardiomyocytes after myocardial infarct.
n/a Ensembl ENSG00000199085 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 7: 25.95 – 25.95 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 148a is a miRNA that in humans is encoded by the MIR148A gene. Function microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in ...
In molecular biology, miR-137 (or microRNA-137) is a short non-coding RNA molecule that functions to regulate the expression levels of other genes by various mechanisms. miR-137 is located on human chromosome 1p22 and has been implicated to act as a tumor suppressor in several cancer types including colorectal cancer, squamous cell carcinoma and melanoma via cell cycle control.