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A 2011 clinical practice guideline supports the use of ketamine as a sedative in emergency medicine, including during physically painful procedures. [21] It is the drug of choice for people in traumatic shock who are at risk of hypotension. [44]
Ketamine’s antidepressant effects are part of what prompted researchers to explore other drugs that target glutamate—like the venerable cough suppressant dextromethorphan found in Robitussin ...
Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
Dr. Mandel: There are about 170 clinical studies on ketamine therapy for depression and other mental health conditions. The results that have been published, about 70 studies, have been ...
Halsey detailed using ketamine therapy to help with PTSD and postpartum depression in an August 2024 episode of the "She MD" podcast."A lot of people have a different experience.
Ketamine has been demonstrated to produce lasting antidepressant effects after administration in a clinical setting. In 2019, esketamine, an NMDA antagonist enantiomer of ketamine, was approved for use as an antidepressant in the United States. [17] In 2022, Auvelity was approved by the FDA for the treatment of depression.
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Psychedelic therapy is contraindicated for people who: [87] [88] [89] are pregnant, have a history of epilepsy/other seizure disorder, have severe cardiovascular disease including uncontrolled blood pressure, heart failure, coronary artery disease, or previous heart attack or stroke, use medications like SSRI or MAO-I antidepressants,