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Alpha-blockers, including prazosin, terazosin, doxazosin, or tamsulosin, do not appear to affect all-cause mortality in heart failure rehospitalization in those also receiving β-blockers. [ 23 ] Tamsulosin can also cause retrograde ejaculation , which occurs when semen is redirected to the urinary bladder instead of being ejaculated normally.
The risk of first dose phenomenon may be reduced or eliminated by gradual-dose titration, since the adverse effects of Prazosin are dose-related. [7] This is also the case for Tamsulosin and it may be assumed that the others alpha-1 blockers work in a similar manner, since Tamsulosin is an alpha-1-a blocker and Prazosin is an alpha-1 blocker. [30]
For instance, alpha blockers that are used for the reduction of blood pressure, such as phenoxybenzamine or phentolamine can have synergy with other drugs that affect smooth muscle, blood vessels, or drugs used for erectile dysfunction (i.e. sildenafil, tamsulosin, etc.).
Some drugs and medications affect heart rate, meaning you may have a lower maximum heart rate and target zone, says Dr. Steinbaum. “If you have a heart condition or take medication, ask your ...
heart failure. The cardio-selective beta-1 blockers could cause adverse effects including bradycardia, reduced exercise ability, hypotension, atrioventricular nodal blockage and heart failure. [5] Other possible adverse effects include nausea and vomiting, abdominal discomfort, dizziness, weakness, headache, fatigue, and dryness in mouth and ...
Selective beta 1 blockers have been shown to have an array of cardiac common side effects, comprising bradycardia, reduced exercise tolerance, hypotension, atrioventricular block, and heart failure. [4] Regarding non-cardiac side effects, they can cause nausea, headache, fatigue, dry mouth, and dry eyes. [4]
Prazosin is active after taken by mouth and has a minimal effect on cardiac function due to its α 1-adrenergic receptor selectivity. When prazosin is started, however, heart rate and contractility can increase in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure ...
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