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  2. Hyper-IgM syndrome type 4 - Wikipedia

    en.wikipedia.org/wiki/Hyper-IgM_syndrome_type_4

    Hyper IgM syndrome can have the following syndromes: [6] [11] Infection/Pneumocystis pneumonia (PCP), which is common in infants with hyper IgM syndrome, is a serious illness. [9] PCP is one of the most frequent and severe opportunistic infections in people with weakened immune systems. Hepatitis (Hepatitis C) Chronic diarrhea; Hypothyroidism ...

  3. Immunoglobulin class switching - Wikipedia

    en.wikipedia.org/wiki/Immunoglobulin_class_switching

    Mechanism of class-switch recombination that allows isotype switching in activated B cells. Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. [1]

  4. Immunoglobulin M - Wikipedia

    en.wikipedia.org/wiki/Immunoglobulin_M

    IgM is the first immunoglobulin expressed in the human fetus (around 20 weeks) [46] and phylogenetically the earliest antibody to develop. [47] IgM antibodies appear early in the course of an infection and usually reappear, to a lesser extent, after further exposure. IgM antibodies do not pass across the human placenta (only isotype IgG). [48]

  5. IgG deficiency - Wikipedia

    en.wikipedia.org/wiki/IgG_deficiency

    IgG deficiency is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes.. IgG deficiency is often found in children as transient hypogammaglobulinemia of infancy, which may occur with or without additional decreases in IgA or IgM.

  6. Isolated primary immunoglobulin M deficiency - Wikipedia

    en.wikipedia.org/wiki/Isolated_primary...

    In addition it was recently described that hypomorphic mutations in the B-cell receptor (BLNK & BTK) lead to selective IgM deficiency. [ 4 ] It is however puzzling that class switching seems to happen normally (serum levels of other antibodies are normal), while dysfunctioning of IgM synthesis is expected to occur together with abnormalities in ...

  7. Dysgammaglobulinemia - Wikipedia

    en.wikipedia.org/wiki/Dysgammaglobulinemia

    IgG deficiency - IgG deficiency is a lack of IgG in the absence of other immunoglobulin deficiencies. IgG levels of 300–600 mg/dL show a mild to moderate reduction of IgG while levels below 200 mg/dl are classified as a severe deficiency. [6] Those with IgG deficiency often get chronic or reoccurring pyogenic respiratory tract infections. [7]

  8. Are NFL quarterbacks worth their high salaries? - AOL

    www.aol.com/sports/nfl-quarterbacks-worth-high...

    Kyler Murray - Contract value: $230.5 million - Career NFL record: 34-43-1 - Approximate career value: 62. 2018 Heisman Trophy winner Kyler Murray was the top pick in the 2019 NFL draft.

  9. Immunoglobulin G - Wikipedia

    en.wikipedia.org/wiki/Immunoglobulin_G

    The water-accessible surface area of an IgG antibody. Immunoglobulin G (IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation. [1] IgG molecules are created and released by plasma B cells. Each IgG antibody has two paratopes.