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Ageing (or aging in American English) is the process of becoming older. The term refers mainly to humans , many other animals , and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal . [ 1 ]
Lenart and Vašku (2016) [45] have also invoked evolvability as the main mechanism driving evolution of ageing. However, they proposed that even though the actual rate of aging can be an adaptation the aging itself is inevitable. In other words, evolution can change the speed of aging but some ageing no matter how slow will always occur.
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.
Development and application of aging clocks and combination therapies A study reports the development of deep learning software using anatomic magnetic resonance images to estimate brain age with the highest accuracy for AI so far, including detecting early signs of Alzheimer's disease and varying neuroanatomical patterns of neurological aging.
It involves interdisciplinary research on the causes, effects, and mechanisms of biological aging. Biogerontologist Leonard Hayflick has said that the natural average lifespan for a human is around 92 years and, if humans do not invent new approaches to treat aging, they will be stuck with this lifespan. [2]
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [1] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [ 2 ]
Aging is associated with many changes in the central nervous system, such as mild atrophy of the cortex, which is considered non-pathological. Aging is also associated with many neurological and neurodegenerative diseases, such as amyotrophic lateral sclerosis , dementia , mild cognitive impairment , Parkinson's disease , and Creutzfeldt ...
In biogerontology, the disposable soma theory of aging states that organisms age due to an evolutionary trade-off between growth, reproduction, and DNA repair maintenance. [1] Formulated by British biologist Thomas Kirkwood , the disposable soma theory explains that an organism only has a limited amount of resources that it can allocate to its ...