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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
Kidney toxicity [5] associated with kidney failure; associated with development of cancer, particularly of the urinary tract, known carcinogen [8] [9] Atractylate Atractylis gummifera: Liver damage, [3] nausea, vomiting, epigastric and abdominal pain, diarrhoea, anxiety, headache and convulsions, often followed by coma [10]
Nevirapine may cause severe or life-threatening liver toxicity, usually emerging in the first six weeks of treatment. [ 25 ] [ 27 ] In 2000, the U.S. Food and Drug Administration issued a black box warning on nevirapine, warning that it could cause life-threatening liver toxicity and skin reactions. [ 4 ]
Drug-drug interactions can be of serious concern for patients who are undergoing multi-drug therapies. [5] Coadministration of chloroquine , an anti-malaria drug, and statins for treatment of cardiovascular diseases has been shown to cause inhibition of organic anion-transporting polypeptides (OATPs) and lead to systemic statin exposure.
Paracetamol toxicity is one of the most common causes of poisoning worldwide. [25] In the United States, the United Kingdom, Australia, and New Zealand, paracetamol is the most common cause of drug overdoses. [20] [92] [93] Additionally, in both the United States and the United Kingdom it is the most common cause of acute liver failure. [94] [9]
There is no evidence of greater liver function changes with higher doses of bicalutamide, and hence the liver toxicity of bicalutamide is not currently known to be dose-dependent across its clinically used dosage range. [164] Older age, for a variety of reasons, appears to be an important risk factor for drug-induced hepatotoxicity.
"Standard preparations of green tea are less likely to cause liver toxicity," Dr. David Kim, MD, hepatologist and gastroenterologist at GI Alliance in Arlington Heights, Illinois, tells Parade ...
They have a direct toxic effect on the liver; cause inflammation of liver caused by and thereby impact lipid metabolism and fatty liver disease; and can translocate from the lungs to the liver. [46] Because particulate matter and carbon black are very diverse and each has different toxicodynamics, detailed mechanisms of translocation are not clear.