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A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver. It can be a side-effect , but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids , or in laboratory environments, such as carbon tetrachloride , or far more pervasively in the form of ethanol (drinking alcohol).
Drugs and other substances that have been associated with significant hepatotoxicity (liver damage). Subcategories ...
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
Hepatic veno-occlusive disease, myelosuppression, cytokine release syndrome, hypersensitivity and electrolyte anomalies. Ibritumomab tiuxetan: IV: CD20 antibody bound with the radioactive isotope, 90Y, induces radiation-dependent cell lysis. Non-Hodgkin's lymphoma and follicular lymphoma.
Hepatotoxicity. [14] Ketorolac: 1993 France, Germany, others Hemorrhage, Kidney Failure. [3] L-tryptophan: 1989 Germany, UK Eosinophilic myalgia syndrome. [3] Still sold in the US Levamisole (Ergamisol) 1999 US Still used as veterinary drug and as a human antihelminthic in many markets; listed on the WHO List of Essential Medicines.
This includes mostly drug-induced hepatotoxicity, (DILI) which may generate many different patterns over liver disease, including cholestasis; necrosis; acute hepatitis and chronic hepatitis of different forms, cirrhosis; Effects of Acetaminophen (Tylenol)
According to 2010 WHO guidelines: depending on the severity of the disease and degree of decompensation, the following regimen can be used, by altering the number of hepatotoxic drugs. One or two hepatotoxic drugs may be used in moderately severe disease (e.g., Childs B cirrhosis) whereas hepatotoxic drugs are completely avoided in ...
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