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To determine an individual's rate of bone turnover, numerous biomarkers are available in the body fluids that can be correlated to this rate, and one such biomarker is NTX. [ 1 ] However, while NTX does fluctuate in a very sensitive manner in line with bone resorption patterns, they are not very specific , in that they may vary spontaneously ...
In the early 2000s, a link between bisphosphonate use and impaired bone physiology was noted. [3] [4] The strong inhibition of osteoclast function precipitated by bisphosphonate therapy can lead to inhibition of normal bone turnover, leading to impaired wound healing following trauma (such as dental surgery) or even spontaneous non-healing bone exposure.
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid [5]) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. [6] Because osteocalcin has gla domains, its synthesis is vitamin K2-dependent. In humans, osteocalcin is encoded by the ...
More recent contributions have been within the area of biochemical bone turnover markers and leadership of clinical trials in the osteoporosis area for new osteoporosis treatments. Eastell is Professor of Bone Metabolism at the University of Sheffield and Director of the Mellanby Centre for Musculoskeletal Research. [5]
12845 Ensembl ENSG00000105664 ENSMUSG00000031849 UniProt P49747 Q9R0G6 RefSeq (mRNA) NM_000095 NM_016685 RefSeq (protein) NP_000086 NP_057894 Location (UCSC) Chr 19: 18.78 – 18.79 Mb Chr 8: 70.83 – 70.83 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily ...
where, is a convolution operator, C bone (t) is the bone tissue activity concentration of tracer (in units: MBq/ml) over a period of time t, C plasma (t) is the plasma concentration of tracer (in units: MBq/ml) over a period of time t, IRF(t) is equal to the sum of exponentials, β values are fixed between 0.0001 sec −1 and 0.1 sec −1 in ...
A 2015 systematic review of biomarkers for osteoarthritis looking for molecules that could be used for risk assessments found 37 different biochemical markers of bone and cartilage turnover in 25 publications. [214]
In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues [ 1 ] to examine normal biological processes , pathogenic processes, or pharmacologic responses to a therapeutic intervention . [ 2 ]