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  2. Immune-mediated thrombocytopaenia - Wikipedia

    en.wikipedia.org/wiki/Immune-mediated...

    The longest time between discharge and relapse was over 3 years. Seven dogs experienced relapse more than once and one dog relapsed five times before being euthanised. [16] In dogs with a platelet count below < 30,000 cells/μL there is an increased risk of spontaneous haemorrhage; [26] however, haemorrhage cannot be predicted in dogs with IMT ...

  3. Canine histiocytic diseases - Wikipedia

    en.wikipedia.org/wiki/Canine_histiocytic_diseases

    They can occur in dogs of all ages, but are more likely in dogs under three years of age. Epidermal invasion by cells of histiocytoma frequently occurs and intra-epidermal nests of histiocytes resemble Pautrier's aggregates, characteristically found in epidermotropic lymphoma (Mycosis Fungoides or MF).

  4. Malignant histiocytosis - Wikipedia

    en.wikipedia.org/wiki/Malignant_histiocytosis

    The source for histiocytes is the monocyte/macrophage line. Monocytes (found in the blood) and macrophages (found in tissue) are responsible for phagocytosis (ingestion) of foreign material in the body. Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and presenting them to T cells.

  5. Histiocytoma (dog) - Wikipedia

    en.wikipedia.org/wiki/Histiocytoma_(dog)

    The source for histiocytes is the monocyte/macrophage line. Monocytes (found in the blood) and macrophages (found in tissue) are responsible for phagocytosis (ingestion) of foreign material in the body. Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and presenting them to T cells.

  6. Phagocytosis - Wikipedia

    en.wikipedia.org/wiki/Phagocytosis

    Macrophages are long-lived and can continue phagocytosis by forming new lysosomes. [11] [13] Dendritic cells also reside in tissues and ingest pathogens by phagocytosis. Their role is not killing or clearance of microbes, but rather breaking them down for antigen presentation to the cells of the adaptive immune system. [11]

  7. Macrophage - Wikipedia

    en.wikipedia.org/wiki/Macrophage

    The activation of T H 1 and M1 macrophage is a positive feedback loop, with IFN-γ from T H 1 cells upregulating CD40 expression on macrophages; the interaction between CD40 on the macrophages and CD40L on T cells activate macrophages to secrete IL-12; and IL-12 promotes more IFN-γ secretion from T H 1 cells.

  8. Mastocytoma in dogs - Wikipedia

    en.wikipedia.org/wiki/Mastocytoma_in_dogs

    Mast cells in cell culture. Mast cells (mastocytes) are cells of the immune system and represent an important link between the innate and acquired immune response.They arise from precursor cells in the bone marrow and migrate as immature cells to many tissues, especially those in close contact with the outside world, where they differentiate.

  9. Macrophage activation syndrome - Wikipedia

    en.wikipedia.org/wiki/Macrophage_activation_syndrome

    There is uncontrolled activation and proliferation of macrophages, and T lymphocytes, with a marked increase in circulating cytokines, such as IFN-gamma, and GM-CSF. The underlying causative event is unclear, and is the subject of ongoing research. In many cases of MAS, a decreased natural killer cell (NK-cell) function is found.