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The therapeutic effect of hypothermia is not confined to metabolism and membrane stability. Hypothermia can also prevent the injuries that occur after circulation returns to the brain, or what is termed reperfusion injuries. In fact, an individual suffering from an ischemic insult continues suffering injuries well after circulation is restored.
Brain failure after clinical death is now known to be due to a complex series of processes called reperfusion injury that occur after blood circulation has been restored, especially processes that interfere with blood circulation during the recovery period. [11] Control of these processes is the subject of ongoing research.
This reperfusion results in inflammatory injury through three overlapping mechanisms. Some complimentary combination of, first, mitochondrial damage and, second, endothelial activation , causes a release of reactive oxygen species (ROS), which initiates and/or exacerbates a pathophysiological inflammatory response.
Targeted temperature management (TTM), previously known as therapeutic hypothermia or protective hypothermia, is an active treatment that tries to achieve and maintain a specific body temperature in a person for a specific duration of time in an effort to improve health outcomes during recovery after a period of stopped blood flow to the brain. [1]
Pet first aid courses are available to pet owners and people who work with pets. This is particularly crucial when determining the type of injury or emergency so that the owner is in a better position to respond appropriately. [4] Many pet related businesses that involve looking after pets require staff to be trained in pet first aid. [5]
Treatment involves scaling and polishing of the teeth under general anesthesia and treatment of any periodontal disease. Prevention is very important and can be accomplished through the use of special diets or treats, brushing, and plaque prevention gels. [183] Portosystemic shunt is a bypass of the liver by the body's circulatory system. It ...
Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, followed by tissue damage associated with re-oxygenation. IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction , ischemic stroke , acute kidney injury , trauma ...
Rescue death (or reflow syndrome) is a hypothesized fatal condition that can occur after blood pools in a part of the body for a prolonged period such as during suspension trauma.
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