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The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone.
The length of the half-life of methadone allows for the exhibition of respiratory depressant effects for an extended duration of time in opioid-naive people. [ 12 ] Methadone at therapeutic concentrations is known to prolong the QTc interval , which indicates that the heart muscle repolarizes more slowly.
A bottle of veterinary pharmaceutical potassium bromide oral solution used in dogs, primarily as an antiepileptic (to stop seizures) [3] In dogs, epilepsy is often an inherited condition. The incidence of epilepsy/seizures in the general dog population is estimated to be between 0.5% and 5.7%. [4]
Opioid agonist therapy (OAT) is a treatment in which prescribed opioid agonists are given to patients who live with Opioid use disorder (OUD). [1] In the case of methadone maintenance treatment (MMT), methadone is used to treat dependence on heroin or other opioids, and is administered on an ongoing basis.
For dogs that are actively having an episode, distraction techniques may be helpful. Talking to the dog or offering food and treats are methods of distraction. Although there is no treatment, prognosis is considered to be good because idiopathic head tremors are benign and do not lead to long term disease or illness. [3]
It is used for operative and accident-related pain in small mammals such as dogs, cats, ferrets, coatis, raccoons, mongooses, various marsupials, some rodents and perhaps some larger birds. Although butorphanol is commonly used for pain relief in reptiles, no studies (as of 2014) have conclusively shown that it is an effective analgesic in ...
Levomethadone is used for narcotic maintenance in place of, or in some cases alongside as an alternative, to racemic methadone, [4] owing to concern about the cardiotoxic and QT-prolonging action of racemic methadone being primarily caused by the dextrorotatory enantiomer, dextromethadone.
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