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Lymphatic filariasis is a human disease caused by parasitic worms known as filarial worms. [2] [3] Usually acquired in childhood, it is a leading cause of permanent disability worldwide, impacting over a hundred million people and manifesting itself in a variety of severe clinical pathologies [6] [7] While most cases have no symptoms, some people develop a syndrome called elephantiasis, which ...
According to the Filarial Genome Project being done by The Special Programme for Research and Training in Tropical Diseases, the Brugia malayi MIF gene is expressed in all life-cycle stages of the parasite, and results suggest that B. malayi MIF may interact with the human immune system during the course of infection by altering the function of ...
Elephantiasis, often incorrectly called elephantitis, is the enlargement and hardening of limbs or body parts due to tissue swelling . [ 1 ] [ 2 ] It is characterised by edema, hypertrophy , and fibrosis of skin and subcutaneous tissues, due to obstruction of lymphatic vessels ( lymphedema ). [ 2 ]
Parasitic worms cannot reproduce entirely within their host's body; they have a life cycle that includes some stages that need to take place outside of the host. [3] Helminths are able to survive in their mammalian hosts for many years due to their ability to manipulate the host's immune response by secreting immunomodulatory products. [ 4 ]
Archaeological evidence for elephantiasis for example extends back some 3000 years, by which time apparently it already was no novelty. [6] Currently perhaps some hundreds of millions of people worldwide, mainly in tropical regions, are infected with pathogenic species of filariae.
Page numbering is the process of applying a sequence of numbers (or letters, or Roman numerals) to the pages of a book or other document. The number itself, which may appear in various places on the page, can be referred to as a page number or as a folio . [ 1 ]
Filariasis is a filarial infection caused by parasitic nematodes (roundworms) spread by different vectors.They are included in the list of neglected tropical diseases.. The most common type is lymphatic filariasis caused by three species of Filaria that are spread by mosquitoes.
Wuchereria bancrofti is a filarial (arthropod-borne) nematode (roundworm) that is the major cause of lymphatic filariasis.It is one of the three parasitic worms, together with Brugia malayi and B. timori, that infect the lymphatic system to cause lymphatic filariasis.