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PubChem CID: 446598; ... Clindamycin is a lincosamide antibiotic medication used for the treatment of a number of bacterial infections, including osteomyelitis ...
Clindamycin/benzoyl peroxide, sold under the brand name Benzaclin among others, is a topical gel used for the treatment of acne. [7] It is a fixed-dose combination of clindamycin , as the phosphate, an antibiotic ; and benzoyl peroxide , an antiseptic .
PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine , which is part of the United States National Institutes of Health (NIH).
It is an alternative treatment for Pneumocystis pneumonia together with clindamycin. [2] [3] It is taken by mouth. [2] Common side effects include nausea, vomiting, and stomach cramps. [2] [4] Primaquine should not be given to people with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of red blood cell breakdown. [4]
Artemotil (INN; also known as β-arteether [1]), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. [2]
A related compound, clindamycin, is derived from lincomycin by using thionyl chloride to replace the 7-hydroxy group with a chlorine atom with inversion of chirality. [4] It was released for medical use in September 1964. [5]
Iboxamycin is a synthetic lincosamide or oxepanoprolinamide antibiotic.It binds to the bacterial ribosome in both Gram-negative and Gram-positive bacteria and it has been found to effective against bacteria which are resistant to other antibiotics that target the large ribosomal subunit.
Indeed, fosmidomycin has been tested in combination treatment with clindamycin for treatment of malaria with favorable results. [ 6 ] [ 7 ] [ 8 ] It has been shown that an increase in copy number of the target enzyme ( DXP reductoisomerase ) correlates with in vitro fosmidomycin resistance in the lethal malaria parasite, Plasmodium falciparum .