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People with K-K syndrome typically show the following symptoms: [5] [6] [7] Intellectual disability; Phalangeal hypoplasia; Post-axial polydactyly; Toe syndactyly (affecting the 2nd and 3rd toes), also known as webbed toes
This is normal in many birds, such as ducks; amphibians, such as frogs; and some mammals, such as kangaroos. In humans it is rare, occurring once in about 2,000 to 2,500 live births: most commonly the second and third toes are webbed (joined by skin and flexible tissue), which can reach partly or almost fully up the toe.
Polysyndactyly is a congenital anomaly, combining polydactyly and syndactyly, in which affected individuals have an extra finger or toe that is connected, via fusing or webbing, to an adjacent digit. [1] [2]
Syndactyly can be simple or complex. [2] In simple syndactyly, adjacent fingers or toes are joined by soft tissue. In complex syndactyly, the bones of adjacent digits are fused. The kangaroo exhibits complex syndactyly. Syndactyly can be complete or incomplete. In complete syndactyly, the skin is joined all the way to the tip of the involved ...
[1] [2] [5] In particular, syndactyly of the third and fourth fingers or the second, third and fourth toes is termed "syndactyly type 1". [1] The degree of syndactyly may differ across affected individuals, with some exhibiting syndactyly of soft tissues and skin only, and more severe cases exhibiting syndactyly of digital bones.
Absent tibia-polydactyly-arachnoid cyst syndrome, also known as Holmes-Collins syndrome, is a very rare multi-systemic hereditary disorder which is characterized by facial dysmorphisms, [1] pre/post-axial polydactyly, toe syndactyly, missing/underdeveloped tibia bone, and the presence of a retrocerebellar arachnoid cyst.
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