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Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1]
The Mouse Genetics Project (MGP) is a large-scale mutant mouse production and phenotyping programme aimed at identifying new model organisms of disease. [1] [2] [3] [4]Based at the Wellcome Trust Sanger Institute, the project uses knockout mice most of which were generated by the International Knockout Mouse Consortium.
The C57BL/6 mouse was the second-ever mammalian species to have its entire genome published. [1] The dark coat makes the mouse strain convenient for creating transgenic mice: it is crossed with a light-furred 129 mouse, and the desirable crosses can be easily identified by their mixed coat colors. [1]
The laboratory mouse genome has been sequenced and many mouse genes have human homologues. [1] Lab mice are sold at pet stores for snake food and can also be kept as pets . Other mouse species sometimes used in laboratory research include two American species, the white-footed mouse ( Peromyscus leucopus ) and the North American deer mouse ...
The mouse genome has been sequenced, and virtually all mouse genes have human homologs. The mouse has approximately 2.7 billion base pairs and 20 pairs of chromosomes. [ 12 ] They can also be manipulated in ways that are illegal with humans, although animal rights activists often object.
The laboratory also provides more than 13,000 strains of mouse models to more than 2,400 organizations in 68 countries around the world. [1] Additionally, JAX is the home of the Mouse Genome Informatics database, and an international hub for scientific courses, conferences, training and education. [7]
MMHCdb is part of the Mouse Genome Informatics consortium (MGI) and was first released in 1998 as the Mouse Tumor Biology (MTB) database. [4] MMHCdb contains genetic and genomic information about inbred mouse strains, genetically engineered mouse models (GEMMs) and Patient Derived Xenograft (PDX) models of human cancer.
In February 1990 Mouse News Letter changed its name to Mouse Genome. In addition to the lists, maps and unrefereed contributions, short refereed papers were published. Starting in 1991 Mouse Genome was published four times a year as one volume with four issues. As before, each issue had a theme and contained contributions and short papers.