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In one case, however, a particular type of collagen graft led to significant delay of wound closure. [6] Careful study of histology samples revealed that grafts that delayed wound closure induced the synthesis of new dermis de novo at the injury site, instead of forming scar, which is the normal outcome of the spontaneous wound healing response.
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Collagen alpha-1(VII) chain is a protein that in humans is encoded by the COL7A1 gene. [5] It is composed of a triple helical, collagenous domain flanked by two non-collagenous domains, and functions as an anchoring fibril between the dermal-epidermal junction in the basement membrane. [ 6 ]
Collagen is one of the body's key natural resources and a component of skin tissue that can benefit all stages of wound healing. [21] When collagen is made available to the wound bed, closure can occur. This avoids wound deterioration and procedures such as amputation.
PRP is derived from the patient's own blood and may contain growth factors that increase collagen production. [3] It can be applied topically to the entire treatment area during and after collagen induction therapy treatments or injected intradermally to scars. Efficacy of the combined treatments remains in question pending scientific studies ...
worldwidewounds.com > Figure 3 - The time relationship between the different processes of wound healing. by Gregory S Schultz, Glenn Ladwig and Annette Wysocki - in turn adapted from Asmussen PD, Sollner B. Mechanism of wound healing. In: Wound Care. Tutorial Medical Series. Stuttgart: Hippokrates Verlag, 1993. Vasoconstriction and vasodilation:
Mechanical tension on a wound has been identified as a leading cause for hypertrophic scar formation. [3] When a normal wound heals, the body produces new collagen fibers at a rate which balances the breakdown of old collagen. Hypertrophic scars are red to brown and thick and may be itchy or painful.
Timing is important to wound healing. Critically, the timing of wound re-epithelialization can decide the outcome of the healing. [11] If the epithelization of tissue over a denuded area is slow, a scar will form over many weeks, or months; [12] [13] If the epithelization of a wounded area is fast, the healing will result in regeneration.