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Pegylated interferon alfa-2b is a drug used to treat melanoma, as an adjuvant therapy to surgery. [3] Also used to treat hepatitis C (typically, in combination with ribavarin), it is no longer recommended due to poor efficacy and adverse side-effects. [4]
Taking this one stage further, the clue word can hint at the word or words to be abbreviated rather than giving the word itself. For example: "About" for C or CA (for "circa"), or RE. "Say" for EG, used to mean "for example". More obscure clue words of this variety include: "Model" for T, referring to the Model T.
For genotype 1 hepatitis C treated with pegylated interferon alfa-2a or pegylated interferon alfa-2b combined with ribavirin, it has been shown that genetic polymorphisms near the human IL28B gene, encoding interferon lambda 3, are associated with significant differences in response to the treatment.
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Pegylated interferon (PEG-IFN) is a class of medication that includes three different drugs as of 2012: [1]. Pegylated interferon-alpha-2a; Pegylated interferon-alpha-2b ...
A crossword (or crossword puzzle) is a word game consisting of a grid of black and white squares, into which solvers enter words or phrases ("entries") crossing each other horizontally ("across") and vertically ("down") according to a set of clues. Each white square is typically filled with one letter, while the black squares are used to ...
A 15x15 lattice-style grid is common for cryptic crosswords. A cryptic crossword is a crossword puzzle in which each clue is a word puzzle. Cryptic crosswords are particularly popular in the United Kingdom, where they originated, [1] as well as Ireland, the Netherlands, and in several Commonwealth nations, including Australia, Canada, India, Kenya, Malta, New Zealand, and South Africa.
He is best known for the invention of the crossword puzzle in 1913, when he was a resident of Cedar Grove, New Jersey. [5] Wynne created the page of puzzles for the "Fun" section of the Sunday edition of the New York World. For the December 21, 1913, edition, he introduced a puzzle with a diamond shape and a hollow center, with the letters F-U ...