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B-lymphocyte antigen CD20 or CD20 is B lymphocyte cell-surface molecule. It is a 33-37 kDa non-glycosylated protein. CD20 is expressed on the surface of B-cells from the pre-B phase, the expression is lost in terminally differentiated plasma cells. [5] [6] CD20 is used as a therapeutical target of B-cell malignancies and autoimmune diseases. [6]
Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...
Roche has an experimental monoclonal antibody in development that targets OX40 (RG7888); anti-OX40 functions as an agonist antibody, which results in activation rather than blockade of the OX40 signaling pathway upon receptor binding; Medimmune AstraZeneca is developing 3 drugs targeting OX40 in colorectal, prostate, breast, and head and neck ...
The laboratory pathologist generally seeks three main histological signs: (1) infiltrating T cells, perhaps accompanied by infiltrating eosinophils, plasma cells, and neutrophils, particularly in telltale ratios, (2) structural compromise of tissue anatomy, varying by tissue type transplanted, and (3) injury to blood vessels. Tissue biopsy is ...
A recent model based on laboratory studies of normal CD19+ B cell, monoclonal CLL/SLL MBL cells, and CLL/SLL malignant cells found that their accumulation of genomic abnormalities may be caused by progressively increasing: 1) double strand breaks in DNA, 2) activation of non-homologous end joining error-prone DNA repair mechanisms, and 3 ...
On average, whole milk contains 3.25% fat—only a few percentage points higher than low-fat milk. To broaden your perspective, half-and-half can contain up to 18% fat, while heavy cream must be ...
Of that weight, 2% milk holds 5 grams of fat and whole milk contains 8 grams. So whole milk isn't much fattier than 2%. In fact, a gallon of 2% has more than half the fat as a gallon of whole milk.
Blood is normally sterile. [1] The presence of bacteria in the blood is termed bacteremia, and the presence of fungi is called fungemia. [2] Minor damage to the skin [3] or mucous membranes, which can occur in situations like toothbrushing or defecation, [4] [5] can introduce bacteria into the bloodstream, but this bacteremia is normally transient and is rarely detected in cultures because the ...