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B-lymphocyte antigen CD20 or CD20 is B lymphocyte cell-surface molecule. It is a 33-37 kDa non-glycosylated protein. CD20 is expressed on the surface of B-cells from the pre-B phase, the expression is lost in terminally differentiated plasma cells. [5] [6] CD20 is used as a therapeutical target of B-cell malignancies and autoimmune diseases. [6]
Hematological malignancies are malignant neoplasms ("cancer"), and they are generally treated by specialists in hematology and/or oncology. In some centers "hematology/oncology" is a single subspecialty of internal medicine while in others they are considered separate divisions (there are also surgical and radiation oncologists).
Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. The anti-CD20 monoclonal antibody Rituximab has been used in lymphocyte predominant Hodgkin lymphoma with encouraging results. [6] BCL6 gene rearrangements have been frequently observed. [7] [8]
Burkitt lymphoma is a very aggressive cancer, which can quickly metastasize and spread throughout the body if the cancer is not treated quickly. If the patient is left untreated, or if treatment is initiated too late, Burkitt lymphoma can be fatal. [4] Burkitt lymphoma in children often has a better prognosis than the same cancer in an adult.
Cow milk consumption in America has drastically declined in recent years as consumers have gravitated towards plant-based milk for health reasons, have an intolerance to dairy, and have ethical ...
Multiple myeloma is the second-most prevalent blood cancer (10%) after non-Hodgkin's lymphoma. [154] It represents about 1.8% of all new cancers and 2.1% of all cancer deaths. [7] Multiple myeloma affects slightly more men than women.
A recent model based on laboratory studies of normal CD19+ B cell, monoclonal CLL/SLL MBL cells, and CLL/SLL malignant cells found that their accumulation of genomic abnormalities may be caused by progressively increasing: 1) double strand breaks in DNA, 2) activation of non-homologous end joining error-prone DNA repair mechanisms, and 3 ...
Researchers discovered that consuming an additional 300 milligrams (mg) of calcium each day, the equivalent of around 1 glass of milk, was associated with a 17% lowered risk for colorectal cancer.