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The alpha-4 beta-2 nicotinic receptor, also known as the α4β2 receptor, is a type of nicotinic acetylcholine receptor implicated in learning, [1] consisting of α4 and β2 subunits. [2] It is located in the brain, where activation yields post-and presynaptic excitation, [2] mainly by increased Na + and K + permeability.
The alpha-2 blocker acts on alpha-2 receptors. The alpha-2 receptor is a G-protein coupled receptor as well, which exert its action by Gi function, leading to an inhibition of adenylyl cyclase and thus reducing synthesis of cAMP. [3] It lowers the amount of calcium inside the cell. [3]
Beta 2 blockers primarily contract the smooth muscles in various tissues, particularly airway smooth muscles where beta 2 receptors are predominantly present. [5] There are currently no FDA-approved beta 2 antagonists for clinical uses. Butoxamine, an example of a beta 2 blocker, is only used in research. [5]
3676 16401 Ensembl ENSG00000115232 ENSMUSG00000027009 UniProt P13612 Q00651 RefSeq (mRNA) NM_000885 NM_001316312 NM_010576 RefSeq (protein) NP_000876 NP_001303241 NP_034706 Location (UCSC) Chr 2: 181.46 – 181.54 Mb Chr 2: 79.09 – 79.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor ...
Neuronal acetylcholine receptor subunit alpha-4, also known as nAChRα4, is a protein that in humans is encoded by the CHRNA4 gene. [5] [6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAChR). Alpha4-containing nAChRs (specifically the alpha4beta2 subtype) appear to play a crucial role in the ...
320910 Ensembl ENSG00000105855 ENSMUSG00000025321 UniProt P26012 Q0VBD0 RefSeq (mRNA) NM_002214 NM_177290 RefSeq (protein) NP_002205 NP_796264 Location (UCSC) Chr 7: 20.33 – 20.42 Mb Chr 12: 119.12 – 119.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. Function This gene is a member of the integrin beta ...
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Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans is encoded by the ITGAL gene. [5] CD11a functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.