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Blepharitis is characterized by chronic inflammation of the eyelid, usually at the base of the eyelashes. [3] [4] [5] Symptoms include inflammation, irritation, itchiness, a burning sensation, excessive tearing, and crusting and sticking of eyelids. [3] [4] Additional symptoms may include visual impairment such as photophobia and blurred vision.
Eyelid edema is a condition in which the eyelids are swollen and tissues contain excess fluid. It may affect eye function when it increases the intraocular pressure. Eyelid edema is caused by allergy, trichiasis or infections. [4] The main symptoms are swollen red eyelids, pain, and itching. Chronic eyelid edema can lead to blepharochalasis.
Periorbital cellulitis, or preseptal cellulitis, is an inflammation and infection of the eyelid and portions of skin around the eye anterior to the orbital septum. [1] It may be caused by breaks in the skin around the eye, and subsequent spread to the eyelid; infection of the sinuses around the nose (); or from spread of an infection elsewhere through the blood.
Blepharochalasis is an inflammation of the eyelid that is characterized by exacerbations and remissions of eyelid edema, which results in a stretching and subsequent atrophy of the eyelid tissue, leading to the formation of redundant folds over the lid margins. It typically affects only the upper eyelids, and may be unilateral as well as ...
The disease is the cause of decreased vision in 2.2 million people, of whom 1.2 million are completely blind. [2] Trachoma is a public health problem in 42 countries across Africa, Asia, the Middle East, and Central and South America. [7] There are 136.9 million people at risk. [2] It results in US$8 billion of economic losses a year. [2]
T h 2 cells and ILC2 cells secrete IL-4, IL-5 and IL-13. [1] [3] IL-4 further drives CD4+ T cell differentiation towards the T h 2 subtype and induces isotype switching to IgE in B cells. IL-4 and IL-13 stimulate trafficking of eosinophils to the site of inflammation, while IL-5 promotes both eosinophil trafficking and production. [2]
Dacryocystitis is an infection of the lacrimal sac, secondary to obstruction of the nasolacrimal duct at the junction of the lacrimal sac. [1] The term derives from Greek dákryon 'tear' cysta 'sac' and -itis 'inflammation'. [2] It causes pain, redness, and swelling over the inner aspect of the lower eyelid and epiphora.
The interior of the eye lacks lymph vessels but is highly vascularized, and many immune cells reside in the uvea, including mostly macrophages, dendritic cells, and mast cells. [1] These cells fight off intraocular infections, and intraocular inflammation can manifest as uveitis (including iritis) or retinitis. The cornea of the eye is ...