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Apraclonidine , also known under the brand name Iopidine, is a sympathomimetic used in glaucoma therapy. It is an α 2 adrenergic receptor agonist and a weak α 1 adrenergic receptor agonist. [ citation needed ]
They are mainly used in research, having found limited clinical application in human medicine. They are extensively used in veterinary medicine to reverse the effects of alpha-2 agonist drugs used as sedatives, like xylazine, medetomidine and dexmedetomidine. Alpha-2 blockers increase noradrenaline release.
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Pilocarpine is a drug that acts as a muscarinic receptor agonist. It acts on a subtype of muscarinic receptor ( M 3 ) found on the iris sphincter muscle , causing the muscle to contract - resulting in pupil constriction ( miosis ).
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